The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private NSF center that helps companies address technical challenges via scalable lab-on-a-chip technology. Through productive, meaningful partnerships between universities and industry, we develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join us and realize key benefits regarding first access to cutting-edge lab-on-a-chip research, recruiting, and relationship building.
Next CADMIM Industrial Advisory Board meeting will be held virtually February 22 – 25, 2021. Agenda here: https://www.inrf.uci.edu/cadmim/iabmeeting/agenda/
This short video, produced by UIDP and featuring CADMIM, presents an overview of the National Science Foundation (NSF) Industry-University Cooperative Research Center (IUCRC) program and how these unique centers operate, contribute to the nation’s research infrastructure base, facilitate technology transfer, and enhance the intellectual capacity of the science and engineering workforce through the integration of research and education.
“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH
“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.
“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory
First CADMIM-funded Non-Provisional Patent Issued
“High-efficiency Encapsulation in Droplets Based on Hydrodynamic Vortices Control,” invented by Gopakumar Kamalakshakurup (now an employee at IAB member Genus PLC) and Abe Lee (CADMIM Director), was issued as a US patent on September 22, 2020. This patent describes an interfacial technique utilizes hydrodynamic micro-vortices to perform (i) high efficiency single cell encapsulation and (ii) size-selective capturing of cells based on their sizes in a single microfluidic device. Single bead/cell encapsulation was demonstrated at 50% efficiency, which is at least 10 times greater than the random encapsulations at the introduced cell concentrations. This issued patent stems from CADMIM-funded project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.” Congratulations to Gopa and Abe! Access US10780438B1 here: CADMIM Issued Patent
2 UCI Undergraduate Students Receive REU Awards
Two Research Experiences for Undergraduate (REU) supplements were awarded to the University of California, Irvine in January 2021. Lily McGrale (in Abe Lee’s Lab) is working on a project entitled “Intracellular Delivery via Acoustic-Electrical Shear Orbiting Poration (AESOP).” Claire Livengood (in Michelle Digman’s Lab) is contributing to “Y6-004: Compound Screening of Cell-Cell Pairing” and other CADMIM projects involving fluorescent lifetime imaging microscopy. Both students will participate in the upcoming CADMIM IAB meeting February 22 – 25, 2021. Congratulations to Lily and Claire!
CADMIM-funded Conference Papers:
- Ssu-Chieh J. Hsu, Wendy Liu, “Microwell-Based Assay Revealed Population Dependent Controls of Macrophage Activation,” BMES 2020 Annual Meeting, October 14 – 17, 2020.
- Jeremy Lombardo, Marzieh Aliaghaei, Jered Haun, “Microfluidic Tissue Processing Platform for Single Cell Analysis and Primary Cell Isolation,” BMES 2020 Annual Meeting, October 14 – 17, 2020.
- Mohammad Aghaamoo, Ruoyu Jiang, Braulio Cardenas Benitez, Abraham P. Lee, “A Microfluidic 3-Part Differential Sorter,” MicroTAS 2020, October 4 – 9, 2020.
- Zhehao Zhang, Ian Papautsky, “Multiplex Sensor for Ion Sensing Based on Printed Circuit Board,” MicroTAS 2020, October 4 – 9, 2020.
CADMIM Co-funded Journal Publication
Adam Szmelter, Jason Jacob, and David Eddington (CADMIM Core Faculty at University of Illinois at Chicago) are the authors of “96-well Oxygen Control Using a 3D-Printed Device.” A pre-print of this CADMIM co-funded paper was posted online at BioRxiv on November 12, 2020.Publication link
New CADMIM Graduates
Congratulations to Lancy Lin (Michelle Khine’s lab), Da Zhao (Abe Lee’s lab), and Jeremy Lombardo (Jered Haun’s lab)! All graduated with PhDs and contributed to various projects at CADMIM.
Jered Haun Launches Start-Up Based on CADMIM-funded Research
The tissue dissociation platform developed in the laboratory of Dr. Jered Haun, CADMIM Core faculty member, is now the basis for a new start-up company, Kino Discovery. This work was selected by NSF to be featured in Chemical Engineering Progress (CEP), and is part of an on-going series highlighting NSF-funded breakthroughs from IUCRCs. UCI’s Henry Samueli School of Engineering posted a related news article entitled “NSF Highlights Haun’s Tissue Dissociation Technology as Breakthrough.” Access CEP article here: CEP CADMIM article. Access UCI article here: UCI HSSoE News Article
Qiyue Luan Receives Award for Graduate Research (AGR)
Ms. Qiyue Luan in the laboratory of Dr. Ian Papautsky (CADMIM Co-Director) is the Fall 2020 Recipient of the Award for Graduate Research (AGR) in Bioengineering at UIC. The AGR is open to all current graduate students. Award funds support travel, summer stipend, or materials/supplies. There are two competitions annually. Congratulations ! List of all Fall 2020 Graduate College award recipients: Recipient list
Hui Lab Captures NSF PFI TT Grant
Congratulations to Dr. Elliot Hui, CADMIM Core faculty! His lab was awarded an NSF Partnerships for Innovation – Technology Translation (PFI-TT) grant entitled “High-Throughput Plant Genetics Platform.” The lab will receive $250,000 over a 2 year performance period. Corporate partners include IAB members KWS SAAT SE & Co. and Corning, Inc. The goal of this project is to further develop a microfluidic device that can sustainably monitor and improve the breeding of agricultural crops. This grant is a result of CADMIM-funded project Y4-006: “Droplet KASP Array.” UCI article about this award: UCI HSSoE article
Other Publications from the University of Illinois at Chicago Site:
- David Kukla, Whitney L. Stoppel, David L. Kaplan, and Salman Khetani, “Assessing the Compatibility of Primary Human Hepatocyte Culture within Porous Silk Sponges” RSC Advances, v. 10, pages 37662-37674, on October 12, 2020. Publication link
- Yuan Gao, Mengren Wu, Yang Lin, Jie Xu, “Trapping and Control of Bubbles in Various Microfluidic Applications,” Lab on a Chip November 13, 2020. Publication link
- Jian Zhou and Ian Papautsky, “Viscoelastic Microﬂuidics: Progress and Challenges” Microsystems and Nanoengineering, December 14, 2020. Publication link
- Jian Zhou and Ian Papautsky, “Resolving dynamics of inertial migration in straight and curved microchannels using through-channel imaging,” Biomicrofluidics, 15(1), January 4, 2021. Publication link
Other Publications from the University of California, Irvine Site:
- Yongxiao Zhou, Eugene Lee, Erik Werner, Michael Chu, Thao Nguyen, Elliot Hui, Kevin Costa, Michelle Khine, “High-Resolution Integrated Piezoresistive Sensors for Microfluidic Monitoring,” Lab on a Chip, December 10, 2020. Publication link
- Stanley C. Liu, Paul Yoo, Neha Garg, Abe Lee, Suraiya Rasheed, “A Microfluidic Device for Blood Plasma Separation and Fluorescence Detection of Biomarkers Using Acoustic Microstreaming,” Sensors and Actuators A: Physical, January 1, 2021. Publication link
- Ruoyu Jiang, Sudhanshu Agrawal, Mohammad Aghaamoo, Ritesh Parajuli, Anshu Agrawal, Abe Lee, “Rapid Isolation of Circulating Cancer Associated Fibroblasts by Acoustic Microstreaming for Assessing Metastatic Propensity of Breast Cancer Patients” Lab on a Chip, December 22, 2020. Publication link
- Tao Yue, Da Zhao, Duc Phan, Xiaolin Wang, Joshua Park, Zayn Biviji, Christopher Hughes, Abraham Lee, “A modular microfluidic system based on multi-layered configuration to generate large scale perfusable microvascular networks,” Microsystems & Nanoengineering, January 6, 2021. Publication link