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The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private consortium that facilitates productive, meaningful partnerships between universities and industry. Our mission is to develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join our National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) and realize key benefits.

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Left: Dr. Ian Papautsky (CADMIM Center Co-Director and University of Illinois at Chicago Site Leader).
Right: Dr. Abraham Lee (CADMIM Center Director and University of California, Irvine Site Leader)


Testimonials

“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH

“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.

“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory


News

Fall IAB Meeting = September 5 – 6, 2018 at the University of Illinois at Chicago.
Agenda: http://www.inrf.uci.edu/cadmim/iabmeeting/agenda/
Travel information & Logistics: http://www.inrf.uci.edu/cadmim/iabmeeting/logistics/
Registration: https://www.regonline.com/cadmim_iab_meeting_2018

UCI Students Intern at Beckman Coulter via NSF INTERN Program
Ms. Esther Chen and Ms. Lancy Lin, PhD candidates at UC Irvine in the laboratories of Dr. Wendy Liu and Dr. Michelle Khine, respectively, will intern at Beckman Coulter (CADMIM IAB member) at the head office in Brea, California. Starting August 2018 and continuing over the following 6 months, both will be assisting the Global Innovation Team in seeking out new applications, markets, and innovative technologies that will guide the company in the development of next generation solutions. Both Esther and Lancy are funded through the NSF INTERN program, which provides funds for internships for graduate students to support career development and opportunities. Congratulations Esther and Lancy! For more information about the NSF INTERN program: https://www.nsf.gov/pubs/2017/nsf17091/nsf17091.jsp

      

CADMIM Receives 2 REU Supplements for 2018
Both sites of CADMIM (University of California Irvine and University of Illinois at Chicago) each received an $8000 supplement from NSF to support undergraduate students. The Research Experiences for Undergraduates (REU) program at NSF provides funds for undergraduates to participate in NSF research activities. UC Irvine’s recipient is Mr. Anthony Cheuk, Biomedical Engineering Department, who is working on CADMIM project “Y4-001: High Density Microfluidic Logic” in Elliot Hui’s lab. UIC’s recipient is Ms. Natalie Vazquez, Bioengineering Department, who is working on “Nuclear Isolation using Inertial Microfluidics” in Ian Papautsky’s lab.  Congratulations to both!

  

Amgen Joins CADMIM
We are very pleased to announce that Amgen, Inc., has joined CADMIM as the newest member of the Industrial Advisory Board. We look forward to working with their delegates at upcoming CADMIM IAB meetings and telecons. Amgen is dedicated to serving patients by transforming the promise of science and biotechnology into therapies that have the power to restore health or save lives. They employ cutting-edge scientific methods to study the subtlest biological mechanisms, leading to the discovery, development, manufacture, and delivery of innovative human therapeutics. Founded in 1980 and headquartered in Thousand Oaks, California, Amgen is one of the world’s largest, independent, multinational biopharmaceutical companies. For more information please visit their website: https://www.amgen.com/

New Patents from CADMIM Faculty
(1) Dr. Elliot Hui (CADMIM Faculty member) and two former students, Dr. Philip Duncan and Mr. Transon Nguyen, filed a US patent application entitled “Microfluidic Oscillator Pump.” This application describes oscillator timing circuits and pumps used to move fluid entirely by the circuits on a microfluidic chip, without the need for off-chip controls. It was published early this year and is now accessible: Pub. No. US 2018/0023552 A1.
(2) In May 2018, a US Patent entitled “Method and Devices for Capturing Circulating Tumor Cells” was granted to the University of Illinois at Chicago. The inventors include David Eddington (CADMIM Faculty member) and Cari Launiere in the Dept. of Bioengineering, and Seung Pyo Hong and Ja Hye Myung in the Dept. of Biopharmaceutical Sciences. Patent no. US 9,964,541 B2 describes a method of capturing a Circulating Tumor Cell (CTC) from a sample using a microfluidic device with both cell capture surfaces and flow modification surfaces.
Congratulations to both teams!

      

UCI CADMIM Students Intern at Major Corporations This Summer
(1) Ms. Neha Garg, PhD candidate at UC Irvine in Dr. Abe Lee’s group, is an intern this summer at GlaxoSmithKline (GSK), CADMIM IAB member. Starting June 2018, and over the next 4 months, Neha will be conducting research in the development of a microfluidic platform for continuous manufacturing of active pharmaceutical ingredients at the Philadelphia, PA, research and development site of GSK under the guidance of Dr. David Lai, Process Engineer at GSK and UCI alum. Congratulations to Neha! For more information about GSK: https://www.gsk.com/
(2) Ms. Xuan Li, PhD candidate at UC Irvine in Dr. Abe Lee’s group, is an intern in the Research and Development Department at Illumina, Inc. in San Diego, CA. Starting June 25, 2018, and over the next 3 months, Xuan will be conducting research in array consumable development for high-throughput genotyping. Congratulations to Xuan! For more information about Illumina: https://www.illumina.com/

      

New Videos Featuring CADMIM Faculty, IAB, and Graduates
(1) Dr. Jason Heikenfeld, CADMIM Faculty member at U. Cincinnati, was a presenter at the 8th Wearable Tech + Digital Health + NeuroTech Silicon Valley conference February 26 – 27, 2018. Click here for his presentation, entitled “Sweat-based Biometric Monitoring, While Active or Resting:” https://www.youtube.com/watch?v=81gwl080DdE
(2) Dr. Brent Ware, recent graduate from Salman Khetani’s laboratory at UIC, was featured in a YouTube video summary of his research. Check out the video here: https://www.youtube.com/watch?v=QisHjpIkook&feature=youtu.be
(3) UCI Media posted a video of Dr. Abe Lee, CADMIM Center Director, speaking about the influences throughout his life that led him to where he is now – truly inspirational! Access Abe’s “What Matters to Me and Why” video here: https://www.youtube.com/watch?v=gC9kTyl8w2U
(4) 7 News Brisbane newscast (Queensland, Australia) featuring Ian Papautsky’s collaborative work on microfluidics for cancer diagnostics with Queensland University of Technology: https://www.facebook.com/7newssydney/videos/2197233526967435/
(5) ALine, Inc., CADMIM IAB member, has a new video overview of their microfluidics company and what they do: https://www.youtube.com/watch?v=kjHC0DzN_Bc&feature=youtu.be

        

New Publications from CADMIM Faculty Laboratories and IAB Members
(1) Xiaolin Wang, Da Zhao, Duc T. T. Phan, Jingquan Liu, Xiang Chen, Bin Yang, Christopher C. W. Hughes, Weijia Zhang, and Abraham Lee (CADMIM Center Director) have published a paper online June 6, 2018 in Lab on a Chip entitled “A Hydrostatic Pressure-Driven Passive Micropump Enhanced with Siphon-based Autofill Function.” The team presents a hydrostatic pressure-driven micropump that can achieve autonomous and continuous fluid perfusion inside a microfluidic chip with long-term, accurately controlled steady flow.  http://dx.doi.org/10.1039/C8LC00236C
(2) The research group Dr. Andrew Steckl, CADMIM faculty member, together with collaborators from the Winkle College of Pharmacy at U. Cincinnati, published a paper in the June 28, 2018 issue of Analytical Methods entitled “Correcting the effect of hematocrit in whole blood coagulation analysis on paper-based lateral flow device.” They describe a no-reaction lateral flow assay device for low-cost blood coagulation monitoring where no conjugate pad or pre-stored reagents are used. This work was funded by Andrew’s NSF PFI:AIR-TT award.  http://dx.doi.org/10.1039/C8AY00192H
(3) Dr. Jason Heikenfeld’s group at U. Cincinnati published “Open Nanofluidic Films with Rapid Transport and No Analyte Exchange for Ultra-low Sample Volumes” in Lab on a Chip July 13, 2018. This paper was authored by Nick Twine, Ryan Norton, Michael Brothers, Adam Hauke, Elliot Gomez, and Jason Heikenfeld. This publication is a result from CADMIM-funded project Y4-009: “Nanofluidic Pre-concentration.” http://pubs.rsc.org/en/content/articlelanding/2018/lc/c8lc00186c#!divAbstract
(4) The Hui and Haun research groups at UCI published “Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells,” in Lab on a Chip August 6, 2018. Full author list: Xiaolong Qiu, Jeremy A. Lombardo, Trisha M. Westerhof, Marissa Pennell, Anita Ng, Hamad Alshetaiwi, Brian M. Luna, Edward L. Nelson, Kai Kessenbrock, Elliot E. Hui, and Jered B. Haun. This publication is a result from CADMIM-funded project Y2-003: “Tissue Processing Chip for Single-Cell Molecular Diagnostics.”
http://pubs.rsc.org/en/content/articlelanding/2018/lc/c8lc00507a/unauth#!divAbstract

      

UC Systemwide Bioengineering Symposium, June 2018 at UC Riverside – Haun Lab Receives Award
This year’s meeting was held at the University of California, Riverside June 21 – 23, 2018. The theme, “Meeting Biomedical Needs with Cutting Edge Science and Technology,” brought together all 10 of the University of California’s campuses with industrial bioengineering leaders to share the latest developments in this field. Dr. Elliot Hui (CADMIM faculty) gave an oral presentation entitled “Computing with Microfluidics,” and Dr. Jered Haun (also CADMIM faculty) was Co-Chair of the Molecular and Cellular Engineering I session. Congratulations to Dr. Maha Rahim, post-doc in the Haun lab, who won Best Oral Presentation in the Bioimaging category for her talk entitled “Transforming FLIM into a High-Content Molecular Analysis Platform.” Center students who presented CADMIM-funded work include Mohammad Aghaamoo (Lee lab), Jeremy Lombardo (Haun Lab), and Erik Werner (Hui Lab). For more information on this event: http://bic2018.engr.ucr.edu/

      
(Left to Right) Jered Haun co-chaired the Molecular and Cellular Engineering I session. Elliot Hui presented his lab’s digital microfludiics work. Dr. Maha Rahim won the “Best Oral Presentation – Bioimaging” award. This award was presented by Dr. Xiaoping Hu, Chair of Bioengineering at UC Riverside and accepted  on Maha’s behalf by Jeremy Lombardo. Click to enlarge photos.

CADMIM Faculty Capture New Funding
(1) Dr. Abe Lee, CADMIM Center Director and Professor in Biomedical Engineering, and Dr. Anshu Agrawal, Assistant Clinical Professor of the Division of Basic and Clinical Immunology in the College of Medicine at UCI, received an R21 grant from the National Institute of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB). The title of the project is “Microfluidic Engineering of Artificial-Antigen Presenting Cells for the Biomanufacturing of Tumor-Specific T-Cells.” The project started in May 2018, total funds = $392,408.
(2) Both Michelle Digman and Michelle Khine(CADMIM faculty members) were awarded UCI Proof-of-Product (POP) grants. Michelle Digman’s project entitled “An Imaging Device to Assess the Developmental Potential of Pre-Implantation Embryos” received $100K. Michelle Khine’s project, entitled “ASPIRE: Asthma Sensing Predictive Intuitive Respiratory E-Alert Monitor” received $50K. Projects commenced May 14, 2018 and will continue for 6 months. For a complete list of awardees: http://innovation.uci.edu/pop-grants-round-3-awardees/

   

Second CADMIM Group Completes NSF I-Corps Program at UCI
Members of Dr. Michelle Digman’s group completed the UCI NSF Innovation-Corps (I-Corps) Site program June 6, 2018. Team members include Dr. Michelle Digman (CADMIM faculty member), Ning Ma (PhD Candidate), Hongtao Chen (Assistant Project Scientist), and Zhenghao Li (graduate student in Computer Science). The team, one of 10 teams in the Spring 2018 Cohort, conducted over 30 customer discovery interviews towards determining the best product/market fit for a device that employs fluorescence lifetime imaging  microscopy (FLIM) to assess the developmental potential of pre-implantation embryos. FLIM was an integral part of CADMIM project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.”

Previously, members of Dr. Abe Lee’s group completed the UCI I-Corps Site program March 14, 2018 to determine the best product/market fit for a microfluidic platform also developed via CADMIM project Y3-002. For more information about this program: http://innovation.uci.edu/programs/i-corps/. The UCI I-Corps Site is part of the national NSF I-Corps National Innovation Network: https://www.nsf.gov/news/special_reports/i-corps/

     
(Left) Second team from CADMIM (Digman lab) completes NSF I-Corps Site course at UCI Applied Innovation. Ning Ma, PhD candidate, poses with UCI I-Corps instructors, Sophia Lin and Doug Crawford. (Right) Previously Abe Lee’s lab completed the course. Left to right in group photo: Doug Crawford, Mohammad Aghaamoo, Gopa Kurup, Gisela Lin, Sophia Lin. Click to enlarge photos.

Michelle Khine Entrepreneurial Leader of the Year Award
On May 14, 2018, UCI Applied Innovation hosted the inaugural UCI Innovator Awards to celebrate researchers and faculty across the campus who are working actively to promote the commercialization of UCI intellectual property. Dr. Michelle Khine received the Entrepreneurial Leader of the Year award to recognize her demonstration of an enterprising spirit and drive by taking one or more significant innovations developed within the university to market-readiness while also providing inspiration and empowerment to others to adopt entrepreneurism. A cash award to support research in the lab accompanies the award, provided by the Beall Family Foundation. Congratulations Michelle! For a complete list of award recipients, see article about this event here: http://innovation.uci.edu/2018/06/inaugural-uci-innovator-awards-ceremony-recognizes-distinguished-researchers-and-inventors/
For a video recap of the event see here: https://indi.com/9fpf6

  
(Left) Michelle Khine (and son!) received the 2018 Entrepreneurial Leader of the Year Award, presented by Dr. Enrique Lavernia, Provost and Executive Vice Chancellor of UC Irvine. (Right) Group photo with all of the evening’s honorees.

Jie Xu Featured in UIC News
Dr. Jie Xu, CADMIM faculty member and Assistant Professor of Mechanical and Industrial Engineering, has begun a new collaboration with Dr. Xuejun Li from the Department of Biomedical Sciences, College of Medicine, with the help of a $10,000 seed grant from the Office of the Vice Chancellor of Research (OVCR), as a result of the UIC Functional and Regenerative Materials Strategic Initiative. The project is entitled “Microfluidics with embedded liquid metal electrodes for human neurons stimulation,” and this collaboration will explore whether human motor neurons and muscle cells can be linked using liquid metal electrodes implemented in microfluidics. The collaboration is the subject of an article posted May 22, 2018 on line and in print. To access the online article: https://today.uic.edu/can-liquid-metals-help-in-nerve-repair

  

Beckman Coulter & UCI Collaboration Recognized by ICTS
On May 4, 2018 the Institute for Clinical and Translational Science (ICTS) at UCI held their annual “Pathways to Cures: Clinical Translational Research Day,” bringing together students, faculty, and community partners for a day of workshops, research posters and presentations, and opportunities to exchange ideas. That evening the longstanding collaboration between Beckman Coulter (BEC)’s Dr. Fiona Adair and UCI Department of Biomedical Engineering’s Dr. Abraham Lee (Chair and CADMIM Director) was honored at the ICTS Awards Dinner, as they are the 2018 recipients of the “Industry-University Partnership Award.” This partnership has spanned over a decade through the public-private consortium, Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) and CADMIM’s predecessor, the Micro/nano Fluidics Fundamentals Focus (MF3) Center. Congratulations to the team!

An article was also posted about the team’s award on the Henry Samueli School of Engineering website: http://engineering.uci.edu/news/2018/5/university-industry-collaboration-honored. For more information about this event: http://www.icts.uci.edu/event/td-2018.php

   
Dr. Fiona Adair and Dr. Abe Lee each take turns addressing the audience during their acceptance speech. Afterwards, Dr. Pramod Khargonekar, Vice Chancellor for Research at UC Irvine, congratulated the team. Click to enlarge photos.

Ian Papautsky and Salman Khetani Receive UIC College of Medicine Awards
On May 9, 2018 both Ian Papautsky, CADMIM Co-director, and Salman Khetani, CADMIM faculty member, received awards from the University of Illinois at Chicago College of Medicine (COM). Ian received the “Faculty of the Year” award, and Salman received the “Departmental Rising Star” award. Dr. Tom Royston, Head of the Dept. of Bioengineering in the COM, described each of these honors:
“Dr. Papautsky’s research has attracted significant support from diverse funding sources that include NIH, NSF, and industry. His work has tremendous potential for point-of-care diagnostics and sensing, and has strong commercial potential. He has demonstrated the highest level of excellence as a researcher and educator, as well as outstanding service to the university and profession.”
“Dr. Khetani is a recognized leading engineer in building advanced human tissue models for drug screening and disease modeling. He has demonstrated the highest level of excellence as a researcher and educator as well as outstanding service to UIC and to his profession.”
Congratulations to both!


[Left to right] Dr. Salman Khetani (Dept. of Bioengineering Rising Star), Dr. Tom Royston (Head of Dept. of Bioengineering), Dr. Ian Papautsky (Faculty of the Year and CADMIM Co-Director)