The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private consortium that facilitates productive, meaningful partnerships between universities and industry. Our mission is to develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join our National Science Foundation (NSF) Industry-University Cooperative Research Center (IUCRC) and realize key benefits.

Phase 2 Kick-off and Spring Industrial Advisory Board Meeting = February 27 – 28, 2019 at the University of California, Irvine.  
On-line registration here: https://secure.touchnet.net/C21570_ustores/web/store_main.jsp?STOREID=195&SINGLESTORE=true
Meeting agenda here: http://www.inrf.uci.edu/cadmim/iabmeeting/agenda/
Travel information & logistics here: http://www.inrf.uci.edu/cadmim/iabmeeting/logistics/

Left: Dr. Ian Papautsky (CADMIM Center Co-Director and University of Illinois at Chicago Site Leader).
Right: Dr. Abraham Lee (CADMIM Center Director and University of California, Irvine Site Leader)

This short video, produced by UIDP and featuring CADMIM, presents an overview of the NSF IUCRC program and how these unique centers operate, contribute to the nation’s research infrastructure base, facilitate technology transfer, and enhance the intellectual capacity of the science and engineering workforce through the integration of research and education.


“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH

“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.

“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory


CADMIM Receives Phase 2 Award from NSF
It’s official! CADMIM will receive a Phase 2 award from NSF. This means CADMIM will be supported for 5 more years starting March 1, 2019. The total award between the 2 center sites (University of California, Irvine and University of Illinois at Chicago) over the 5 year period is $1.25M! Dr. Abe Lee, Center Director, had this to say: “We are excited to launch the next phase of CADMIM! It is gratifying to know that NSF is recognizing and rewarding the many accomplishments of CADMIM in the first 5 years, in research, in technology transfer, and most importantly, in building a community of students, faculty, and industrial members that bridge advanced research with real-world applications.” Many thanks to all the students, post-docs, faculty, and IAB members, past and present, for contributing to the center’s success!

Both UCI and UIC have posted articles about CADMIM’s Phase 2 renewal:
UCI article: http://engineering.uci.edu/news/2018/11/nsf-grant-supports-center-develop-microfluidics-based-solutions
UIC article: https://today.uic.edu/nsf-grant-supports-center-to-develop-microfluidics-based-solutions

CADMIM was widely represented at the Biomedical Engineering Society (BMES) Annual Meeting held October 17 – 20, 2018 in Atlanta, Georgia. 8 presentations from the Khetani lab alone! 2 each for David Kukla, Grace Brown, Jennifer Liu, and Chase Monckton. Jeremy Lombardo (UCI) presented CADMIM-funded research in his poster entitled “Microfluidic Device for Efficiently Filtering and Dissociating Digested Tissue into Single Cells.” Complete author list: Jeremy Lombardo, Xiaolong Qiu, Trisha Westerhof, Marissa Pennell, Edward Nelson, and Jered Haun. Also, CADMIM Director, Dr. Abe Lee, was elected to the Biomedical Engineering Society 2018 Class of Fellows (see below). At the conference, Dr. Lee was officially recognized as a fellow. For more information about this event: https://www.bmes.org/annualmeeting


Corning Joins CADMIM
We are very pleased to announce that Corning, Inc., has joined CADMIM as the newest member of the Industrial Advisory Board. We look forward to working with their delegates at upcoming CADMIM IAB meetings and telecons. Corning is one of the world’s leading innovators in materials science, Corning possesses unparalleled expertise in glass science, ceramics science, and optical physics as well as deep manufacturing and engineering capabilities to develop life-changing innovations and products. For more information please visit their website: http://www.corning.com/

CADMIM UIDP Webinar Broadcasted October 10
CADMIM was featured in the UIDP webinar series on October 10, 2018. UIDP is an organization whose mission is to strengthen industry-university collaborations. National Science Foundation (NSF) IUCRCs like CADMIM are uniquely positioned to do just that, and UIDP has created an entire webinar series featuring various IUCRCs around the country. See webinar details on the flyer below (click to enlarge). The CADMIM webinar was recorded and available on the UIDP website here: https://www.uidp.org/nsf-iucrc-webinars/.

Ning Ma Wins Maschoff Brennan Innovation Scholarship
Maschoff Brennan awarded a $2,500 Innovation Scholarship to Ms. Ning Ma, CADMIM PhD candidate in Dr. Michelle Digman’s group at UC Irvine, during the Orange County Business Journal’s Innovator of the Year Awards. Maschoff Brennan is among the leading intellectual property and complex litigation law firms, and winners were nominated by their peers. Ning has been developing an FLIM-based imaging system that helps evaluate the viability of embryos during in vitro fertilization. Congratulations Ning! Details here: Maschoff Brennan Innovator Scholarship. UCI Applied Innovation article here: UCI Students Recognized

Another Great IAB Meeting!
So nice to see everyone at the CADMIM Industrial Advisory Board (IAB) meeting September 5 – 6, 2018 at the University of Illinois at Chicago (UIC). Many thanks to our IAB members, faculty, post-docs, and students who participated in this event and made it a huge success! More photos from this event here: http://www.inrf.uci.edu/cadmim/about-cadmim/photos/sept2018/. The following Sunday (Sept. 9) the UIC CADMIM groups went to the Chicago White Sox game, where they played none other than the Los Angeles Angels of Anaheim! In the spirit of CADMIM, our UIC site managed to get a microfluidics Sox-o-gram posted in the stadium! Click photo to enlarge and look closely at the red arrow.

Ian Papautsky Receives NIH R33 Grant
Dr. Ian Papautsky, CADMIM Co-Director, received a 3-year grant is for $1.8M with an effective start date of September 1, 2018. Dr. Erin Haynes (U. Cincinnati) is a subcontracting collaborator on the grant, entitled, “Validation and Demonstration of Point-of-Care Sensor for Multi-Metal Exposure Assessment.” This team is developing a portable, smartphone-sized sensor that measures human exposure to lead, manganese and possibly other toxic metals using a single finger prick of blood. This work was featured today on WTTW – Window To The World. WTTW is a premier public media organization committed to creating and presenting independent, unique television and digital media content. Access the article here: https://chicagotonight.wttw.com/2018/09/12/uic-professor-developing-finger-prick-blood-test-toxic-metals
This work was also featured in EurekAlert!: https://www.eurekalert.org/pub_releases/2018-09/uoia-pst091318.php

UCI CADMIM Faculty Recieve Top Honors
(1) Congratulations to CADMIM Director, Abe Lee, who was elected to the Biomedical Engineering Society 2018 Class of Fellows, awarded to society members who demonstrate exceptional achievements in the field of biomedical engineering. A full list of 2018 fellow can be found here: https://www.bmes.org/blog_home.asp?Display=133. UCI article about Dr. Lee’s election: http://engineering.uci.edu/news/2018/9/lee-elected-bmes-fellow
(2) Dr. Michelle Digman was elected to serve a 3-year term on the Biophysical Society (BPS) Council, the group’s governing body, beginning March 2019. Congratulations! For more information: http://engineering.uci.edu/news/2018/8/digman-elected-bps-council


UCI Students Intern at Beckman Coulter via NSF INTERN Program
Ms. Esther Chen and Ms. Lancy Lin, PhD candidates at UC Irvine in the laboratories of Dr. Wendy Liu and Dr. Michelle Khine, respectively, will intern at Beckman Coulter (CADMIM IAB member) at the head office in Brea, California. Starting August 2018 and continuing over the following 6 months, both will be assisting the Global Innovation Team in seeking out new applications, markets, and innovative technologies that will guide the company in the development of next generation solutions. Both Esther and Lancy are funded through the NSF INTERN program, which provides funds for internships for graduate students to support career development and opportunities. Congratulations Esther and Lancy! For more information about the NSF INTERN program: https://www.nsf.gov/pubs/2017/nsf17091/nsf17091.jsp


CADMIM Receives 2 REU Supplements for 2018
Both sites of CADMIM (University of California Irvine and University of Illinois at Chicago) each received an $8000 supplement from NSF to support undergraduate students. The Research Experiences for Undergraduates (REU) program at NSF provides funds for undergraduates to participate in NSF research activities. UC Irvine’s recipient is Mr. Anthony Cheuk, Biomedical Engineering Department, who is working on CADMIM project “Y4-001: High Density Microfluidic Logic” in Elliot Hui’s lab. UIC’s recipient is Ms. Natalie Vazquez, Bioengineering Department, who is working on “Nuclear Isolation using Inertial Microfluidics” in Ian Papautsky’s lab.  Both students presented posters at the Fall IAB meeting in Chicago. Congratulations to both!


New Patents from CADMIM Faculty
(1) Dr. Elliot Hui (CADMIM Faculty member) and two former students, Dr. Philip Duncan and Mr. Transon Nguyen, filed a US patent application entitled “Microfluidic Oscillator Pump.” This application describes oscillator timing circuits and pumps used to move fluid entirely by the circuits on a microfluidic chip, without the need for off-chip controls. It was published early this year and is now accessible: Pub. No. US 2018/0023552 A1.
(2) In May 2018, a US Patent entitled “Method and Devices for Capturing Circulating Tumor Cells” was granted to the University of Illinois at Chicago. The inventors include David Eddington (CADMIM Faculty member) and Cari Launiere in the Dept. of Bioengineering, and Seung Pyo Hong and Ja Hye Myung in the Dept. of Biopharmaceutical Sciences. Patent no. US 9,964,541 B2 describes a method of capturing a Circulating Tumor Cell (CTC) from a sample using a microfluidic device with both cell capture surfaces and flow modification surfaces.
Congratulations to both teams!


New Videos Featuring CADMIM Faculty, IAB, and Graduates
(1) Dr. Jason Heikenfeld, CADMIM Faculty member at U. Cincinnati, was a presenter at the 8th Wearable Tech + Digital Health + NeuroTech Silicon Valley conference February 26 – 27, 2018. Click here for his presentation, entitled “Sweat-based Biometric Monitoring, While Active or Resting:” https://www.youtube.com/watch?v=81gwl080DdE
(2) Dr. Brent Ware, recent graduate from Salman Khetani’s laboratory at UIC, was featured in a YouTube video summary of his research. Check out the video here: https://www.youtube.com/watch?v=QisHjpIkook&feature=youtu.be
(3) UCI Media posted a video of Dr. Abe Lee, CADMIM Center Director, speaking about the influences throughout his life that led him to where he is now – truly inspirational! Access Abe’s “What Matters to Me and Why” video here: https://www.youtube.com/watch?v=gC9kTyl8w2U
(4) 7 News Brisbane newscast (Queensland, Australia) featuring Ian Papautsky’s collaborative work on microfluidics for cancer diagnostics with Queensland University of Technology: https://www.facebook.com/7newssydney/videos/2197233526967435/
(5) ALine, Inc., CADMIM IAB member, has a new video overview of their microfluidics company and what they do: https://www.youtube.com/watch?v=kjHC0DzN_Bc&feature=youtu.be


Latest Publications from CADMIM Research Groups:
(1) The Hui and Haun research groups at UCI jointly published “Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells,” in Lab on a Chip August 6, 2018. Full author list: Xiaolong Qiu, Jeremy A. Lombardo, Trisha M. Westerhof, Marissa Pennell, Anita Ng, Hamad Alshetaiwi, Brian M. Luna, Edward L. Nelson, Kai Kessenbrock, Elliot E. Hui, and Jered B. Haun. This publication is a result from CADMIM-funded project Y2-003: “Tissue Processing Chip for Single-Cell Molecular Diagnostics.” Access here: https://pubs.rsc.org/en/content/articlelanding/2018/lc/c8lc00507a#!divAbstract
(2) Xuan Li, Mohammad Aghaamoo, Shiyue Liu, Do-Hyun Lee, and Abraham P. Lee, “Lipoplex-Mediated Single-Cell Transfection via Droplet Microfluidics.” This paper was published in Small on line September 10, 2018. Access it here: https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.201802055
(3) Do-Hyun Lee, Xuan Li, Alan Jiang, and Abraham P. Lee, “An Integrated Microfluidic Platform for Size-selective Single-Cell Trapping of Monocytes from Blood.” This paper was published in Biomicrofluidics on line September 19, 2018. Access it here: https://aip.scitation.org/doi/abs/10.1063/1.5049149
(4) Vanessa Herrera, Ssu-Chieh Joseph Hsu, Maha K. Rahim, Carol Chen, Lisa Nguyen, Wendy F. Liu, Jered B. Haun, “Pushing the limits of detection for proteins secreted from single cells using quantum dots,” This paper was published in Analyst on line September 26, 2018. Access it here: https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01083h#!divAbstract


UC Systemwide Bioengineering Symposium, June 2018 at UC Riverside – Haun Lab Receives Award
This year’s meeting was held at the University of California, Riverside June 21 – 23, 2018. The theme, “Meeting Biomedical Needs with Cutting Edge Science and Technology,” brought together all 10 of the University of California’s campuses with industrial bioengineering leaders to share the latest developments in this field. Dr. Elliot Hui (CADMIM faculty) gave an oral presentation entitled “Computing with Microfluidics,” and Dr. Jered Haun (also CADMIM faculty) was Co-Chair of the Molecular and Cellular Engineering I session. Congratulations to Dr. Maha Rahim, post-doc in the Haun lab, who won Best Oral Presentation in the Bioimaging category for her talk entitled “Transforming FLIM into a High-Content Molecular Analysis Platform.” Center students who presented CADMIM-funded work include Mohammad Aghaamoo (Lee lab), Jeremy Lombardo (Haun Lab), and Erik Werner (Hui Lab). For more information on this event: http://bic2018.engr.ucr.edu/

(Left to Right) Jered Haun co-chaired the Molecular and Cellular Engineering I session. Elliot Hui presented his lab’s digital microfludiics work. Dr. Maha Rahim won the “Best Oral Presentation – Bioimaging” award. This award was presented by Dr. Xiaoping Hu, Chair of Bioengineering at UC Riverside and accepted  on Maha’s behalf by Jeremy Lombardo. Click to enlarge photos.

Second CADMIM Group Completes NSF I-Corps Program at UCI
Members of Dr. Michelle Digman’s group completed the UCI NSF Innovation-Corps (I-Corps) Site program June 6, 2018. Team members include Dr. Michelle Digman (CADMIM faculty member), Ning Ma (PhD Candidate), Hongtao Chen (Assistant Project Scientist), and Zhenghao Li (graduate student in Computer Science). The team, one of 10 teams in the Spring 2018 Cohort, conducted over 30 customer discovery interviews towards determining the best product/market fit for a device that employs fluorescence lifetime imaging  microscopy (FLIM) to assess the developmental potential of pre-implantation embryos. FLIM was an integral part of CADMIM project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.”

Previously, members of Dr. Abe Lee’s group completed the UCI I-Corps Site program March 14, 2018 to determine the best product/market fit for a microfluidic platform also developed via CADMIM project Y3-002. For more information about this program: http://innovation.uci.edu/programs/i-corps/. The UCI I-Corps Site is part of the national NSF I-Corps National Innovation Network: https://www.nsf.gov/news/special_reports/i-corps/

(Left) Second team from CADMIM (Digman lab) completes NSF I-Corps Site course at UCI Applied Innovation. Ning Ma, PhD candidate, poses with UCI I-Corps instructors, Sophia Lin and Doug Crawford. (Right) Previously Abe Lee’s lab completed the course. Left to right in group photo: Doug Crawford, Mohammad Aghaamoo, Gopa Kurup, Gisela Lin, Sophia Lin. Click to enlarge photos.

Michelle Khine Entrepreneurial Leader of the Year Award
On May 14, 2018, UCI Applied Innovation hosted the inaugural UCI Innovator Awards to celebrate researchers and faculty across the campus who are working actively to promote the commercialization of UCI intellectual property. Dr. Michelle Khine received the Entrepreneurial Leader of the Year award to recognize her demonstration of an enterprising spirit and drive by taking one or more significant innovations developed within the university to market-readiness while also providing inspiration and empowerment to others to adopt entrepreneurism. A cash award to support research in the lab accompanies the award, provided by the Beall Family Foundation. Congratulations Michelle! For a complete list of award recipients, see article about this event here: http://innovation.uci.edu/2018/06/inaugural-uci-innovator-awards-ceremony-recognizes-distinguished-researchers-and-inventors/
For a video recap of the event see here: https://indi.com/9fpf6

(Left) Michelle Khine (and son!) received the 2018 Entrepreneurial Leader of the Year Award, presented by Dr. Enrique Lavernia, Provost and Executive Vice Chancellor of UC Irvine. (Right) Group photo with all of the evening’s honorees.

Jie Xu Featured in UIC News
Dr. Jie Xu, CADMIM faculty member and Assistant Professor of Mechanical and Industrial Engineering, has begun a new collaboration with Dr. Xuejun Li from the Department of Biomedical Sciences, College of Medicine, with the help of a $10,000 seed grant from the Office of the Vice Chancellor of Research (OVCR), as a result of the UIC Functional and Regenerative Materials Strategic Initiative. The project is entitled “Microfluidics with embedded liquid metal electrodes for human neurons stimulation,” and this collaboration will explore whether human motor neurons and muscle cells can be linked using liquid metal electrodes implemented in microfluidics. The collaboration is the subject of an article posted May 22, 2018 on line and in print. To access the online article: https://today.uic.edu/can-liquid-metals-help-in-nerve-repair


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