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The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private consortium that facilitates productive, meaningful partnerships between universities and industry. Our mission is to develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join our National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) and realize key benefits.

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Left: Dr. Ian Papautsky (CADMIM Center Co-Director and University of Illinois at Chicago Site Leader).
Right: Dr. Abraham Lee (CADMIM Center Director and University of California, Irvine Site Leader)


Testimonials

“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH

“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.

“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory


News

Fall IAB Meeting = September 5 – 6, 2018 at the University of Illinois at Chicago.
Agenda: http://www.inrf.uci.edu/cadmim/iabmeeting/agenda/
Travel information & Logistics: http://www.inrf.uci.edu/cadmim/iabmeeting/logistics/


Jie Xu Featured in UIC News

Dr. Jie Xu, CADMIM faculty member and Assistant Professor of Mechanical and Industrial Engineering, has begun a new collaboration with Dr. Xuejun Li from the Department of Biomedical Sciences, College of Medicine, with the help of a $10,000 seed grant from the Office of the Vice Chancellor of Research (OVCR), as a result of the UIC Functional and Regenerative Materials Strategic Initiative. The project is entitled “Microfluidics with embedded liquid metal electrodes for human neurons stimulation,” and this collaboration will explore whether human motor neurons and muscle cells can be linked using liquid metal electrodes implemented in microfluidics. The collaboration is the subject of an article posted May 22, 2018 on line and in print. UIC News is printed weekly during the Fall and Spring semesters, and the newspaper is distributed on campus and in the surrounding neighborhoods
To access the online article: https://today.uic.edu/can-liquid-metals-help-in-nerve-repair

  

Beckman Coulter & UCI Collaboration Recognized by ICTS
On May 4, 2018 the Institute for Clinical and Translational Science (ICTS) at UCI held their annual “Pathways to Cures: Clinical Translational Research Day,” bringing together students, faculty, and community partners for a day of workshops, research posters and presentations, and opportunities to exchange ideas. That evening the longstanding collaboration between Beckman Coulter (BEC)’s Dr. Fiona Adair and UCI Department of Biomedical Engineering’s Dr. Abraham Lee (Chair and CADMIM Director) was honored at the ICTS Awards Dinner, as they are the 2018 recipients of the “Industry-University Partnership Award.” This partnership has spanned over a decade through the public-private consortium, Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) and CADMIM’s predecessor, the Micro/nano Fluidics Fundamentals Focus (MF3) Center. Congratulations to the team!

An article was also posted about the team’s award on the Henry Samueli School of Engineering website: http://engineering.uci.edu/news/2018/5/university-industry-collaboration-honored. For more information about this event: http://www.icts.uci.edu/event/td-2018.php

   
Dr. Fiona Adair and Dr. Abe Lee each take turns addressing the audience during their acceptance speech. Afterwards, Dr. Pramod Khargonekar, Vice Chancellor for Research at UC Irvine, congratulated the team. Click to enlarge photos.

Ian Papautsky and Salman Khetani Receive UIC College of Medicine Awards
On May 9, 2018 both Ian Papautsky, CADMIM Co-director, and Salman Khetani, CADMIM faculty member, received awards from the University of Illinois at Chicago College of Medicine (COM). Ian received the “Faculty of the Year” award, and Salman received the “Departmental Rising Star” award. Dr. Tom Royston, Head of the Dept. of Bioengineering in the COM, described each of these honors:
“Dr. Papautsky’s research has attracted significant support from diverse funding sources that include NIH, NSF, and industry. His work has tremendous potential for point-of-care diagnostics and sensing, and has strong commercial potential. He has demonstrated the highest level of excellence as a researcher and educator, as well as outstanding service to the university and profession.”
“Dr. Khetani is a recognized leading engineer in building advanced human tissue models for drug screening and disease modeling. He has demonstrated the highest level of excellence as a researcher and educator as well as outstanding service to UIC and to his profession.”
Congratulations to both!


[Left to right] Dr. Salman Khetani (Dept. of Bioengineering Rising Star), Dr. Tom Royston (Head of Dept. of Bioengineering), Dr. Ian Papautsky (Faculty of the Year and CADMIM Co-Director)

New Collaborative Publication from Digman and Lee Labs
The research groups of Dr. Michelle Digman, CADMIM Faculty member, and Dr. Abe Lee, CADMIM Director, was just published in Lab on a Chip. “Rapid and Label-free Identification of Single Leukemia Cells from Blood in a High-Density Microfluidic Trapping Array by Fluorescence Lifetime Imaging Microscopy,” by Do-Hyun Lee, Xuan Li, Ning Ma, Michelle Digman, and Abe Lee, was first published on line March 31, 2018 and will appear in the May 7, 2018 issue (volume 18, issue 9, pp. 1349 – 1358). Congratulations to both labs! This work was partly funded by an NSF Partnerships for Innovation: Accelerating Innovation Research – Research Alliance (PFI:AIR-RA) award. To access online: http://pubs.rsc.org/en/Content/ArticleLanding/2018/LC/C7LC01301A#!divAbstract

    

UIC Bioengineering Hosts First Annual Research Symposium
The University of Illinois at Chicago Richard and Loan Hill Bioengineering Department held their inaugural Research Symposium April 20, 2018 at the Student Center East Tower. This event is hosted by the Biomedical Engineering Society (BMES) and co-organized by Dr. Salman Khetani, CADMIM faculty member. This event was well attended, and Salman was interviewed along with several students and UIC BMES officers. Two of Salman’s students won awards at this event! Congratulations to Mr. David Kukla who won “Best Podium Presentation” and to Ms. Grace Brown who took first place in the Graduate Poster Category. Click here for YouTube video showing highlights from this event: https://www.youtube.com/watch?v=3MuEX7l-vNA&feature=youtu.be

    
Both Dr. Salman Khetani and Ms. Grace Brown were interviewed at the First Annual Bioengineering Research Symposium in the UIC Richard and Loan Hill Bioengineering Department, hosted by BMES April 20, 2018. Click to enlarge photos.

CADMIM at Microfluidics in Hematology Workshop
Abe Lee, CADMIM Director, is the Co-chair of the Microfluidics in Hematology Workshop to be held April 23 – 24, 2018 in Boston, MA. This workshop will bring basic biologists and clinicians in hematology and microfluidics engineers together to discuss the challenges, brainstorm the provocative questions, and foster the interaction between basic research, clinical application, and engineering. The topics to be covered include microfluidic blood cell sorting, cell-based immunotherapies, and the diagnosis and treatment of hematologic malignancies. CADMIM Presentations include:

  • “Whole Blood Sample Preparation by Acoustic Streaming,” Abe Lee (UC Irvine)
  • “Label-free separation of cells from whole blood,” Ian Papautsky (U. Illinois at Chicago)
  •  “Whole Blood Coagulation Monitoring Using Capillary Fluid Flow in Cellulose-Based Devices,” Andrew Steckl (U. Cincinnati)
  •  “Rapid and label-free identification of leukemia cells from blood in a high-density microfluidic single-cell array via Fluorescence Lifetime Imaging Microscopy,” Xuan Li (Graduate student in Lee Lab, UC Irvine)
  • “Lateral migration of cells within whole blood in microfluidic channels,” Poster from Papautsky Lab, presented by Jian Zhou
  •  “Cell Separation and Enrichment in Sheath-flow Inertial Microfluidic Platform,” Poster from Papautsky Lab, presented by Prithvi Mukherjee

CADMIM Faculty and IAB are also on the Technical Program Committee: Abe Lee, Ian Papautsky, Andrew Steckl, and David Yang (Beckman Coulter). Please see workshop website for agenda and details: https://cbmsociety.org/conferences/microhematology/

    
[Left to right] (a) Ian Papautsky, Prithvi Mukherjee (U. Illinois at Chicago), Abe Lee, Xuan Li (UC Irvine). (b) Ian Papautsky (U. Illinois at Chicago), Abe Lee (UC Irvine), David Yang (Beckman Coulter), and Andrew Steckl (U. Cincinnati)

Ian Papautsky –  AIMBE Fellow, Class of 2018
Congratulations to Dr. Ian Papautsky, CADMIM Co-Director, on his induction to the American Institute for Medical and Biological Engineering (AIMBE)’s College of Fellows Class of 2018! Ian’s induction ceremony was held April 8 – 9, 2018 in Washington, DC at the National Academy of Sciences. AIMBE is the most prestigious society medical and biological engineering has to offer. Founded in 1991, AIMBE serves to advocate on issues impacting the medical and biological engineering community. Throughout AIMBE’s history, they have been a driving force in the advancement and innovations in the medical and biological engineering community. AIMBE played a pivotal role in helping to establish the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health. For more information about AIMBE College of Fellows: http://aimbe.org/college-of-fellows/about/

Ian joins Dr. Abe Lee, CADMIM Director, and Dr. Michelle Khine, CADMIM Faculty member, as an AIMBE Fellow. Abe was inducted in 2006, and Michelle in 2015. Ian, Abe, and Michelle are part of a select group (top 2%) of most accomplished medical and biological engineers that make up the College of Fellows.

    
[Left to Right]: (a) Ian Papautsky immediately after induction ceremony. (b) Ian, Dr. Tom Royston (UIC Bioengineering Department Head), and Dr. James Patton (fellow inductee and UIC Bioengineering faculty). (c) AIMBE Induction Ceremony venue. Click to enlarge photos.

CADMIM & DuPont Pioneer Collaboration Featured in the Media
UCI Applied Innovation assembled a special Spring 2018 issue of their quarterly publication, Tech Currents, that focuses on corporate engagement. This issue highlights CADMIM and the way we foster industry/university collaborations. As an example, the article highlights the long-term, productive working relationship between DuPont Pioneer (CADMIM founding IAB member) and the UCI laboratory of Dr. Abe Lee (CADMIM Center Director). This collaboration has taken on various forms throughout the years, including projects funded through CADMIM, sponsored research, and an NSF translational research grant. We certainly look forward to more productive years to come!
Access online version of the article here, posted April 5, 2018 (article appears in print as well): Tech Currents Spring 2018 CADMIM article

  
Photos of the DuPont/UCI collaborative team at the February 2018 CADMIM IAB meeting (left) and March 2017 CADMIM IAB meeting (right). Click to enlarge photos.

Abe Lee Introduces New Start-up Company: Kino Biosciences
Dr. Abe Lee, Center Director, co-founded a new start-up company, Kino Biosciences, along with Dr. Francis Duhay, former Chief Medical Officer at Edwards Lifesciences, Dr. Steven George (UC Davis), Dr. Chris Hughes (UCI), and Dr. Hugh Bender. The core technology is based on a vascularized microphysiological platform co-developed by the founders and extensively published in the literature over the last 5 years. A portion of this work appeared in “A Vascularized and Perfused Organ-on-a-Chip Platform for Large-Scale Drug Screening Applications,” one of the top 10 most downloaded articles published in Lab on a Chip in 2017. For more information about this new company, check out their website (launched March 13, 2018): http://www.kinobio.com/

   

CADMIM Faculty Capture External Funds
Dr. David Eddington, CADMIM Faculty member at the University of Illinois at Chicago, was just awarded an R21 grant from the National Institute of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) in the amount of $410K over 2 years starting April 1, 2018. The title of this project is “3D Printed High Throughput Microfluidic Platform to Generate Microenvironmental Oxygen and Hydrogen Sulfide Landscapes.” Dr. Eddington, PI, is joined by Co-PIs Dr. Jalees Rehman (Dept. of Pharmacology) and Dr. Tom Driver (Dept. of Chemistry). Congratulations to the team!

In addition, Dr. Wendy Liu and Dr. Michelle Khine, CADMIM Faculty at UC Irvine, were each awarded Pilot Grants by the UCI Institute for Clinical and Translational Science (ICTS). A total of eight $25K awards were made. Wendy’s group is conducting research on immunomodulatory biomaterials for use in wound care. Michelle’s group will be working on conformable wearable electronics to monitor congestive heart failure (CHF). Congratulations to both! For more information: http://engineering.uci.edu/news/2018/3/biomedical-engineers-earn-funding-innovative-projects

    

CADMIM Group Completes NSF I-Corps Program at UCI
Members of Dr. Abe Lee’s group completed the UCI NSF Innovation-Corps (I-Corps) Site program March 14, 2018. The team, consisting of Dr. Abe Lee (CADMIM Director), Dr. Gisela Lin (CADMIM Deputy Director), Dr. Gopa Kurup (Post-doc, Lee Group), and Mr. Mohammad Aghaamoo (Graduate Student, Lee Group), conducted over 30 customer discovery interviews towards determining the best product/market fit for the microfluidic platform developed via CADMIM project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.” This team, one of 10 teams in the Winter 2018 Cohort, is the first from CADMIM to complete this I-Corps Site program. Many thanks to Dr. Paul Rounding, PR Bioconsulting, who served as the team’s industrial mentor, and to our IAB members who were interviewed as part of this process!
For more information about this program, housed at UCI Applied Innovation: http://innovation.uci.edu/programs/i-corps/. The UCI I-Corps Site is part of the national NSF I-Corps National Innovation Network: https://www.nsf.gov/news/special_reports/i-corps/

     
First team from CADMIM completes NSF I-Corps Site course at UCI Applied Innovation. Left to right in group photo: Doug Crawford (instructor), Mohammad Aghaamoo, Gopa Kurup, Gisela Lin, Sophia Lin (instructor). Not pictured: Abe Lee, Paul Rounding. Click to enlarge photos.

New Publication from Lee Group
The research group of Dr. Abe Lee, CADMIM Director, just published a new paper in Microsystems and Nanoengineering, a Nature Publishing Group journal with open access and continuous online publication. “Whole-blood Sorting, Enrichment, and in-situ Immunolabeling of Cellular Subsets Using Acoustic Microstreaming,” by Neha Garg, Trisha M. Westerhof, Vick Liu, Robin Liu, Edward L. Nelson, and Abraham P. Lee was published online February 26, 2018. This work, co-funded by CADMIM, is a collaboration between multiple entities at UC Irvine (Henry Samueli School of Engineering, School of Medicine, and Chao Family Comprehensive Cancer Center), Massachusetts Institute of Technology, and Hochuen Medical Technology Company, Ltd. Congratulations to the team! To access this online article, see here: https://www.nature.com/articles/micronano201785

   

Another great CADMIM IAB Meeting! 
So nice to see everyone at the CADMIM Industrial Advisory Board (IAB) meeting February 14 – 15, 2018 at the University of California, Irvine. The annual project portfolio has been selected – see list here: http://www.inrf.uci.edu/cadmim/research-projects/
Many thanks to our IAB members, faculty, post-docs, and students who participated in this event and made it a huge success! We look forward to seeing everyone again in Chicago in September.
Click on photos below to enlarge. More photos from this event here: February 2018 IAB meeting photos