The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private NSF center that helps companies address technical challenges via scalable lab-on-a-chip technology. Through productive, meaningful partnerships between universities and industry, we develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join us and realize key benefits regarding first access to cutting-edge lab-on-a-chip research, recruiting, and relationship building.
Next CADMIM Industrial Advisory Board meeting will be held September 13 – 14, 2022 at the University of Illinois at Chicago and online (hybrid).
This short video, produced by UIDP and featuring CADMIM, presents an overview of the National Science Foundation (NSF) Industry-University Cooperative Research Center (IUCRC) program and how these unique centers operate, contribute to the nation’s research infrastructure base, facilitate technology transfer, and enhance the intellectual capacity of the science and engineering workforce through the integration of research and education.
“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH
“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.
“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory
Successful Spring CADMIM IAB Meeting
Many thanks to everyone who attended the Spring 2022 CADMIM IAB meeting! Great to see so many of you in person at the University of California, Irvine and reconnect with those who participated online. Also many thanks to all the students and post-docs who prepared the posters, slide decks, and videos! Congratulations to our new IAB leaders and poster contest winners. More photos from the event here: CADMIM IAB Meeting photos Spring 2022
4 CADMIM Undergrads Receive REU Supplements
Two Research Experiences for Undergraduate (REU) supplements were awarded to the University of California, Irvine in March 2022. Ms. Veena Naveen (in Jered Haun’s Lab) is working on a project entitled “Multiplexed Single Cell Immunoassay.” Mr. Amod Bhole (in Elliot Hui’s Lab) is contributing to CADMIM project “Low-Shear Organoid Vortex Array (LOVA)” and other projects involving organoids.
Two additional REU supplements were awarded to the University of Illinois at Chicago in March 2022. Ms. Lesly Villarreal (in Salman Khetani’s Lab) is working on a project entitled “Platforms for the Control and Sensing of Oxygen Tensions in Human Liver Cultures for Drug Screening and Disease Modeling.” Ms. Lubna Shah (in Zhangli Peng’s Lab) is working on a project entitled “Revealing the Inertial Focusing Mechanisms in Curved and Triangular Channels by Computational Modeling.” Congratulations to all students!
Michelle Digman and Wendy Liu Inducted into AIMBE’s College of Fellows
Congratulations to Dr. Michelle Digman, CADMIM Core Faculty, and Dr. Wendy Liu, CADMIM Affiliated Faculty. They are among 152 medical and biological engineers inducted into the American Institute for Medical and Biological Engineering’s College of Fellows Class of 2022 on March 25, 2022! They are part of a select group (top 2%) of most accomplished medical and biological engineers that make up the College of Fellows. Michelle and Wendy join Dr. Abe Lee, CADMIM Director, Dr. Ian Papautsky, CADMIM Co-Director, and Dr. Michelle Khine, CADMIM Affiliated Faculty, as AIMBE Fellows. For more information about AIMBE College of Fellows: http://aimbe.org/college-of-fellows/about/.
For a complete list of 2022 fellows: https://aimbe.org/2022-aimbe-fellows/
UCI article published online: UCI article
UCI CADMIM Team Complete NSF I-Corps Programs
Members of Dr. Michelle Digman’s group completed the UCI NSF Innovation-Corps (I-Corps) Site program March 9, 2021. Team members include Michelle Digman (CADMIM Core Faculty), Dr. Francesco Palomba, PhD (Post-graduate researcher), and Ms. Song Zhu (PhD Graduate Student). The team, one of 10 teams in the Winter 2022 Cohort, conducted over 30 customer discovery interviews towards determining the best product/market fit for a label-free platform to screen embryo viability. For more information about NSF I-Corps Team and Site programs: NSF I-Corps
CADMIM Supports 2 Undergraduate Student Design Teams at UCI
This academic year, CADMIM is supporting 2 undergraduate senior design teams in the UCI BME 180 class (the Biomedical Engineering Capstone Design course):
- Project title: “Low-cost Point-of-care Device to Detect Cerebrospinal Fluid (CSF) Leakage”
Faculty Mentor = Dr. Michelle Khine
Student Mentor = Ms. Julia Zakashansky
Corporate Mentor = Dr. David Yang, Danaher Corp
Team Members = Arushi S., Stephanie Lunar, Briana Peterson, John Polvi, Nathaniel Silva, Seemal Tahir
- Project title: “Low-cost, 3D-printed Open Flexure Microscope Capable of Transmission, Fluorescence, and Hyperspectral Imaging”
Faculty Mentor = Dr. Michelle Digman
Post-doc Mentor = Dr. Francesco Palomba, PhD
Industry Mentor = Dr. Lancy Lin, Thermo Fisher Scientific
Team Members = Luis Escalante, Gia Ferrante, Mohammad Alfeerawi, Alyssia Fossorier, Kevin Kathrotia
CADMIM Graduate Students Intern at Companies via NSF INTERN Program
Mr. Mengren Wu, PhD Candidate in the laboratory of Dr. Jie Xu, CADMIM Core faculty at University of Illinois at Chicago, started an internship in January 2022 at Vena Vitals, Inc., supported by the NSF INTERN program. Vena Vitals is a start-up company in Irvine, California, emerging from the laboratory of Dr. Michelle Khine (CADMIM Affiliated faculty at UC Irvine).
Ms. Elena Boselli, PhD Candidate in the laboratory of Dr. Ian Papautsky, CADMIM Co-Director at the University of Illinois at Chicago, started an internship at KWS SAAT SE & Co. KGaA in January 2022, also supported by the NSF INTERN program. KWS is a European independent company based in Germany that focuses on plant breeding. Both students will intern for 6 months. Congratulations to both!
CADMIM Ph.D. Graduates
Congratulations to Trinh Lam (David Eddington’s lab) and Julia Zakashansky (Michelle Khine’s lab)! Both graduated with PhDs and contributed to various projects at CADMIM.
CADMIM-funded Journal Publications
- Review paper published January 2022 in Biosensors. Xuhao (Evan) Luo, Becky (Jui-Yi) Chen, Marzieh Ataei, and Abe Lee (CADMIM Center Director),“Microfluidic Compartmentalization Platforms for Single Cell Analysis.” Access paper here: https://www.mdpi.com/2079-6374/12/2/58
Marzieh Aliaghaei, Jered Haun, “Optimization of Mechanical Tissue Dissociation Using and Integrated Microfluidic Device for Improved Generation of Single Cells Following Digestion,” Frontiers in Bioengineering and Biotechnology, February 8, 2022. Access paper: https://www.frontiersin.org/articles/10.3389/fbioe.2022.841046/full