The Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) is a public-private NSF center that helps companies address technical challenges via scalable lab-on-a-chip technology. Through productive, meaningful partnerships between universities and industry, we develop microscale tools and technologies aimed at simpler, faster, and cheaper analytical solutions addressing human health, agriculture, and the environment. Join us and realize key benefits regarding first access to cutting-edge lab-on-a-chip research, recruiting, and relationship building.
Next CADMIM Industrial Advisory Board meeting will be held September 8 – 9, 2021 at the University of Illinois at Chicago.
This short video, produced by UIDP and featuring CADMIM, presents an overview of the National Science Foundation (NSF) Industry-University Cooperative Research Center (IUCRC) program and how these unique centers operate, contribute to the nation’s research infrastructure base, facilitate technology transfer, and enhance the intellectual capacity of the science and engineering workforce through the integration of research and education.
“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH
“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.
“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory
Successful Spring Industrial Advisory Board Meeting
The Spring 2021 Industrial Advisory Board meeting was held virtually February 22 – 25, 2021. Faculty presented new project ideas, and we had a highly interactive poster session. Congratulations to the new leaders of the CADMIM Industrial Advisory Board (IAB). For the 2021 – 2022 term Bob Cobene, Senior Project Engineer at Corning, Inc. will serve as IAB Chair, and John Delaney, Director of Research Technology Prospecting and Collaborations at Amgen, Inc. will serve as IAB Vice-Chair. Many thanks to everyone who participated, especially the students and post-docs! More screenshots from this event can be found here: Spring 2021 IAB Meeting Screenshots
2 CADMIM-funded Non-Provisional Patents Issued
“High-efficiency Encapsulation in Droplets Based on Hydrodynamic Vortices Control,” invented by Gopakumar Kamalakshakurup (now an employee at IAB member Genus PLC) and Abe Lee (CADMIM Director), was issued as a US patent on September 22, 2020. This patent stems from CADMIM-funded project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.” Access US10780438B1 here: https://uspto.report/patent/grant/10,780,438
“Microfluidic Device for the Digestion of Tissues into Cellular Suspensions,” invented by Jered Haun, Xiaolong Qiu, Elliot Hui, Amrith Karunaratne, and Erik Werner, was issued a US patent on February 23, 2021. This patent stems from CADMIM-funded project Y2-003: “Tissue Processing Chip for Single-cell Molecular Diagnostics.” Access US10926257B1 here: https://patents.justia.com/patent/10926257
4 Undergraduate Students Receive CADMIM REU Awards
Two Research Experiences for Undergraduate (REU) supplements were awarded to the University of California, Irvine in January 2021. Lily McGrale (in Abe Lee’s Lab) is working on a project entitled “Intracellular Delivery via Acoustic-Electrical Shear Orbiting Poration (AESOP).” Claire Livengood (in Michelle Digman’s Lab) is contributing to “Y6-004: Compound Screening of Cell-Cell Pairing” and other CADMIM projects involving fluorescent lifetime imaging microscopy. Two additional REU supplements were awarded to the University of Illinois at Chicago February 2021. Amanda Bogseth (in Ian Papautsky’s lab) is working on a project entitled “Microfluidics for Cell Cycle Studies.” Rana Abbed (in David Eddington’s lab) is working on a project entitled “3D Printing for Cell Culture Applications.” Congratulations to all!
CADMIM Co-funded Journal Publication
Adam Szmelter, Jason Jacob, and David Eddington (CADMIM Core Faculty at University of Illinois at Chicago) are the authors of “96-well Oxygen Control Using a 3D-Printed Device.” This CADMIM co-funded paper was published online in Analytical Chemistry on January 18, 2021. Congratulations to the team! Publication link
New CADMIM Graduates
Congratulations to Lancy Lin (Michelle Khine’s lab), Da Zhao (Abe Lee’s lab), and Jeremy Lombardo (Jered Haun’s lab)! All graduated with PhDs and contributed to various projects at CADMIM.
Qiyue Luan Receives Award for Graduate Research (AGR)
Ms. Qiyue Luan in the laboratory of Dr. Ian Papautsky (CADMIM Co-Director) is the Fall 2020 Recipient of the Award for Graduate Research (AGR) in Bioengineering at UIC. The AGR is open to all current graduate students. Award funds support travel, summer stipend, or materials/supplies. There are two competitions annually. Congratulations ! List of all Fall 2020 Graduate College award recipients: Recipient list
Other Publications from the University of Illinois at Chicago Site:
- David Kukla, Whitney L. Stoppel, David L. Kaplan, and Salman Khetani, “Assessing the Compatibility of Primary Human Hepatocyte Culture within Porous Silk Sponges” RSC Advances, v. 10, pages 37662-37674, on October 12, 2020. Publication link
- Yuan Gao, Mengren Wu, Yang Lin, Jie Xu, “Trapping and Control of Bubbles in Various Microfluidic Applications,” Lab on a Chip November 13, 2020. Publication link
- Jian Zhou and Ian Papautsky, “Viscoelastic Microﬂuidics: Progress and Challenges” Microsystems and Nanoengineering, December 14, 2020. Publication link
- Jian Zhou and Ian Papautsky, “Resolving dynamics of inertial migration in straight and curved microchannels using through-channel imaging,” Biomicrofluidics, 15(1), January 4, 2021. Publication link
Other Publications from the University of California, Irvine Site:
- Yongxiao Zhou, Eugene Lee, Erik Werner, Michael Chu, Thao Nguyen, Elliot Hui, Kevin Costa, Michelle Khine, “High-Resolution Integrated Piezoresistive Sensors for Microfluidic Monitoring,” Lab on a Chip, December 10, 2020. Publication link
- Stanley C. Liu, Paul Yoo, Neha Garg, Abe Lee, Suraiya Rasheed, “A Microfluidic Device for Blood Plasma Separation and Fluorescence Detection of Biomarkers Using Acoustic Microstreaming,” Sensors and Actuators A: Physical, January 1, 2021. Publication link
- Ruoyu Jiang, Sudhanshu Agrawal, Mohammad Aghaamoo, Ritesh Parajuli, Anshu Agrawal, Abe Lee, “Rapid Isolation of Circulating Cancer Associated Fibroblasts by Acoustic Microstreaming for Assessing Metastatic Propensity of Breast Cancer Patients” Lab on a Chip, December 22, 2020. Publication link
- Tao Yue, Da Zhao, Duc Phan, Xiaolin Wang, Joshua Park, Zayn Biviji, Christopher Hughes, Abraham Lee, “A modular microfluidic system based on multi-layered configuration to generate large scale perfusable microvascular networks,” Microsystems & Nanoengineering, January 6, 2021. Publication link