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Welcome!

Thank you for visiting the Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM). We are a National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC). Our mission is to develop design tools and manufacturing technologies for integrated microfluidics targeting cost-effective, quick, and easy assessment of the environment, agriculture, and human health. Get involved in this world-class, leading-edge NSF I/UCRC! Join our organization and realize key benefits.

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Left: Dr. Ian Papautsky (CADMIM Center Co-Director and University of Illinois at Chicago Site Leader).
Right: Dr. Abraham Lee (CADMIM Center Director and University of California, Irvine Site Leader)


Testimonials

“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH

“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.

“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory


News

Next CADMIM IAB Meeting Feb. 14 – 15, 2018 at UC Irvine
The next CADMIM Industrial Advisory Board meeting will be held February 14 – 15, 2018 at the University of California, Irvine. This will be a project selection meeting.
Registration here: https://www.regonline.com/builder/site/?eventid=2093213
Agenda here: http://www.inrf.uci.edu/cadmim/iabmeeting/agenda/
Travel information and registration here: http://www.inrf.uci.edu/cadmim/iabmeeting/logistics/

Wearable Sensors Critical Review Paper Published in Lab on a Chip
CADMIM Faculty members Jason Heikenfeld and Michelle Khine, along with other prominent researchers in the wearable sensor field, have published a critical review paper entitled “Wearable Sensors: Modalities, Challenges, and Prospects.” This paper was published as an advance article in Lab on a Chip November 28, 2017, and covers the recent successes and fundamental obstacles in this field. To access it see here:
http://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc00914c#!divAbstract

  
The state-of-the-art wearable sensors featured in the review paper include a sweat sensor, developed by the Heikenfeld group at the University of Cincinnati (left), and a wearable strain sensor, developed by the Khine group at the University of California, Irvine (right). 

Abe Lee and MicroTAS 2017 Featured on HSSoE Website
The Henry Samueli School of Engineering (HSSoE) website at UC Irvine featured Dr. Abe Lee, CADMIM Center Director, in a short article about co-chairing the 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), held in Savannah, Georgia, October 22 – 26, 2017. See here: http://engineering.uci.edu/news/2017/11/lee-co-chairs-global-conference

CADMIM and Papautsky Lab Featured in UIC Annual Report
The Richard and Loan Hill Department of Bioengineering at the University of Illinois at Chicago (UIC) recently released their 2016 – 2017 Annual Report. Pages 18 – 19 feature an article about Ian Papautsky (CADMIM Co-Director), his research group, CADMIM, and the last IAB meeting we held at UIC. See PDF version of the article here: UIC_Bioeng_Annual_Report_2017 – Papautsky_CADMIM
To see the entire 2016 – 2017 Annual Report: http://web.bioe.uic.edu/bioe-wp/bioe-about/UIC_Bioengineering_Annual_Report_2017.pdf
Link to Ian Papautsky Group website: http://papautsky.lab.uic.edu/

    
Ian Papautsky’s research group was featured in the UIC Bioengineering Dept. Annual Report, along with CADMIM and the Fall CADMIM IAB meeting. Click to enlarge images. More photos from the IAB meeting can be found in the photo archive under the “About CADMIM” tab.

CADMIM Publication in Lab on a Chip
Dr. Gopakumar Kamalakshakurup, post-doctoral researcher and Dr. Abraham P. Lee, CADMIM Center Director, both at University of California Irvine, have published their work entitled “High-Efficiency Single Cell Encapsulation and Size Selective Capture of Cells in Picoliter Droplets based on Hydrodynamic Micro-vortices” in Lab on a Chip. Published online October 23, 2017, this work was funded by CADMIM via project Y3-002: “Droplet-based Single Cell Assays – from Phenotype to Genotype.” Congratulations Gopa & Abe!
Paper abstract here: http://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc00972k#!divAbstract

   
Beads and cells can be trapped, then released into individual droplets (10um beads shown here). Click photo to enlarge.

2 MicroTAS Student Prize winners From CADMIM
(1) Adam Hauke (U. Cincinnati) won the CHEMINAS Young Researcher Poster Award for his poster entitled “An Integrated Microfluidic System for Continuous Wearable Sweat Sampling and Sensing: Solving Issues with nL Sample Volumes and Skin Contamination.” Full author list: Adam Hauke, Nick Twine, Phillip Simmers, Zach Sonner, Ryan Norton, and Jason Heikenfeld. Only 3 posters received this award, out of ~ 700 total posters presented. This award is sponsored by The Society for Chemistry and Micro-Nano Systems (CHEMINAS) to recognize excellence among conference participants. In addition to recognition, Adam also received a $500 cash prize. We would especially like to recognize the contributions of Nick Twine (MS student) and Ryan Norton (former co-op) to this work. Congratulations to the team!

(2) Sthitodhi Ghosh (U. Cincinnati) won the 3rd place Hochuen Portable Microfluidic Award. Sponsored by Hochuen International Corporation, these awards recognize significant progress and innovative excellence in portable devices. Portable device entries must be smaller than 50 inch3 (or 820 cc) and should not require a tethered external power supply (solar or other power harvesting is permissible as well as use of a smart phone or wireless device for programming and control). Entries were judged on 1. Innovation, 2. Functionality, 3. Ease of Use, and 4. Applications enabled. In addition to recognition, Sthitodhi received a $250 cash prize. This winning device is featured his conference paper (presented at the podium) entitled “A New Mobile Healthcare System Using Smartphone and Lab-on-a-Chip for On-Site Diagnostics of Malaria.” Full author list: Sthitodhi Ghosh, Kashish Aggarwal, Chong H. Ahn. Congratulations to all!

For a complete list of winners for all competitions and categories, see here: http://www.microtas2017.org/welcome/winners.html

       

Click on images to enlarge

CADMIM Publication in IEEE Sensors
Dr. Vishak Venkatraman and Dr. Andrew Steckl, CADMIM faculty member at University of Cincinnati, have published their work entitled “Quantitative Detection in Lateral Flow Immunoassay using Integrated Organic Optoelectronics” in IEEE Sensors Journal. Published online October 18, 2017, this work was funded by CADMIM via project Y2-002: “NFC-Operated Quantitative Point-of-care Diagnostic Assays with Low-to-Zero On-Board Power.” Vishak graduated from the University of Cincinnati in May 2017 and is now a postdoctoral researcher at Northwestern University. Congratulations Vishak & Andrew!
Paper abstract here: http://ieeexplore.ieee.org/document/8070930/

     
Paper describes the integration of organic optoelectronics (light emission and detection) with lateral flow immunoassay (LFIA) paper-based biosensor that uses capillary action for transportation of fluids. Click photo to enlarge.

Jason Heikenfeld Receives Technology Commercialization Award for Biosensor
Dr. Jason Heikenfeld, CADMIM Faculty member and Professor of Electrical Engineering and Computing Systems at U. Cincinnati, has been honored with the second-annual Technology Commercialization Award from the Ohio Faculty Council for his biosensor that stimulates sweat even while a patient is cool and resting. This sensor was recently published in the August 2017 issue of Lab on a Chip (Inside Cover Article). This work was partially funded by CADMIM. Congratulations Jason!
For more information see: http://www.uc.edu/news/NR.aspx?id=25645
For a related article that appeared in the UC Magazine August 3, 2017: http://magazine.uc.edu/editors_picks/recent_features/Sweat.html


The sensor, about the size of a Band-Aid, uses a low electric current and carbachol gel to stimulate sweat under it. Click photo to enlarge.

Ian Papautsky Receives Endowed Named Professorship
Congratulations to Dr. Ian Papautsky, CADMIM Co-Director and Professor in Bioengineering at UIC. On September 18, 2017 Ian was honored at an investiture ceremony as the recipient of the Richard and Loan Hill Professorship in Bioengineering. Richard Hill and his wife, Loan, are major supporters of the UIC Colleges of Engineering and Medicine. Richard Hill is the former CEO of Novellus Systems, one of the top 10 semiconductor equipment manufacturers in the world. Congratulations to Ian on this prestigious award! For more information: https://engineering.uic.edu/2017/10/31/hill-professorships-now-total-six/

   
Photos from Ian’s investiture ceremony. (Left) From Left to Right: Vice Chancellor for Health Affairs, Dr. Robert Barish, Dr. Ian Papautsky, Dean of Engineering Dr. Peter Nelson, and Dean of Medicine Dr. Dimitri Azar. (Right) Two prominent faculty from the University of Cincinnati were also present to honor Ian at the ceremony: Dr. Bill Heineman, world renowned chemist and one of Ian’s mentors, and Dr. Chong Ahn, CADMIM faculty member and microfluidics pioneer. Click photos to enlarge.

Our First CADMIM IAB meeting at UIC
The Fall Industrial Advisory Board meeting was held at the University of Illinois Chicago September 12 – 13, 2017. Great seeing everyone in the windy city! Students and post-docs updated everyone on project progress, and we welcomed UIC faculty and students to the center. We look forward to spending more time in Chicago in the years to come! See photos from this event here: http://www.inrf.uci.edu/cadmim/about-cadmim/photos/

Many thanks to UIC for hosting a great IAB meeting! Click photo to enlarge.

GSK Joins CADMIM
We welcome GlaxoSmithKline (GSK) to the center as a new IAB member! GSK is a science-led global healthcare company that that operates three global businesses that research, develop and manufacture innovative pharmaceutical medicines, vaccines, and consumer healthcare products. GSK’s Pharmaceutical business has a broad portfolio of innovative and established medicines, and is currently focused on developing new medicines in respiratory and HIV/infectious diseases, oncology and immuno-inflammation; with discovery research exploring these and other areas. GSK’s Vaccines business has a broad portfolio and innovative pipeline of vaccines to protect people of all ages and delivers over two million vaccine doses per day to people living in over 160 countries. GSK’s Consumer Healthcare business develops and markets consumer preferred and expert recommended brands in the Oral Health, Pain Relief, Respiratory, Nutrition/Gastro-intestinal and Skin Health categories. For more information please visit their website: www.gsk.com

Jered Haun & Elliot Hui Receive Chan Zuckerberg Grant
CADMIM Faculty members at UCI, Jered Haun (PI) ad Elliot Hui (Co-PI), have received a $240K, 1-year grant from the Chan Zuckerberg Initiative to develop multiple microfluidic components for dissociating human tissues into single cell suspensions. This grant, which commenced September 1, 2017, is entitled “Microfluidic platform for rapid and efficient isolation of single cells from tissue,” stems from previous CADMIM-funded work. Congratulations to Jered and Elliot! For more information about the Chan Zuckerberg initiative: https://chanzuckerberg.com/

   

Michelle Digman Earns Moore Foundation Grant
Michelle Digman, assistant professor of biomedical engineering at UCI and CADMIM faculty member, has been selected for a $56K Scialog Fellow grant from the Research Corporation for Scientific Advancement and the Gordon and Betty Moore Foundation. Michelle is one of 51 Scialog Fellows — outstanding early to mid-career researchers from U.S. academic institutions – who are part of an initiative to develop innovative ideas through research, dialog and collaboration. Congratulations Michelle! For more information: http://engineering.uci.edu/news/2017/9/digman-earns-moore-foundation-grant


CADMIM Receives 2 REU Supplements
Both sites of CADMIM (University of California Irvine and University of Illinois at Chicago) each received an $8000 supplement from NSF to support undergraduate students at CADMIM. The Research Experiences for Undergraduates (REU) program at NSF provides funds for undergraduates to participate in NSF research activities. UC Irvine’s recipient is Mr. Andrew Duncan, Physical Sciences Department, who will be working on CADMIM project “Y4-005: The Ultimate Sample Preparation for Whole Blood” in Dr. Abe Lee’s lab. UIC’s recipient is Ms. Dominique Stewart, Bioengineering Department, who will be working on “Elastomeric Pneumatic Positive and Vacuum Pressure Oscillator Without Electronics” in Dr. David Eddington’s lab. Both students participated in the CADMIM IAB meeting in Chicago. Congratulations to both!

    

(Left) Andrew Duncan, presenting a poster with graduate student Neha Garg, discusses the project with Genentech IAB member, Tim Dawes. (Right) Dominique Stewart discusses research with faculty advisor, Dr. David Eddington, and graduate student Theodore Christoforidis. Click on photos to enlage.