Thank you for visiting the Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM). We are a National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC). Our mission is to develop design tools and manufacturing technologies for integrated microfludics targeting cost-effective, quick, and easy assessment of the environment, agriculture, and human health. Get involved in this world-class, cutting-edge NSF I/UCRC! Join our organization and reap the many benefits.

For a 1-page summary of the CADMIM mission and vision, download the following document: CADMIM_Mission_Vision_statement

Check out our LinkedIn page! CADMIM LinkedIn

Download brochure about CADMIM here (front side shown below): CADMIM brochure



“Our CADMIM membership is pivotal in building a network with world leading experts in microfluidics. CADMIM enabled us to conduct research projects at the transition from basic research to industrial application expanding our capabilities far beyond internal expertise. Combined with the focus on manufacturability the center offers a unique set of expertise and opportunities.”
– Dr. Frank Narz, Director R&D Scientific Applications, QIAGEN GmbH

“CADMIM offers a unique blend of university research from leading researchers in the field supported by leading providers of microfluidic manufacture and development. For the industrial members of CADMIM, who are interested in new product opportunities, this means novel IP is quickly reduced to practice for real world applications.”
– Dr. Leanna Levine, Founder, President and CEO, ALine, Inc.

“With tight research budgets, CADMIM offers an opportunity to leverage industrial investments. We’ve been able to guide world-class research in microfluidics toward challenges in technology development that are barriers to transition. Working in partnership with other members of the industrial advisory board has also brought valuable insight to our programs.”
– Dr. Laura Rea, Program Manager, Soft Matter Materials Branch, Air Force Research Laboratory


Another Great IAB Meeting!
Many thanks to everyone who came to UC Irvine March 1 – 2, 2017 for the semiannual CADMIM Industrial Advisory Board meeting. Welcome to new IAB members Los Alamos National Labs and Genentech Inc.! The IAB worked hard to define our annual research portfolio (so many great projects to choose from, formulated by our talented faculty).
For a list of current projects see here: CADMIM Research
For more photos from this event click here: March 2017 IAB meeting photos 

CADMIM was  also featured in the bimonthly UCI Applied Innovation publication, Tech Currents. This publication also has a companion blog and details the latest events and activities occurring at UCI Applied Innovation and the surrounding business community. Photos from the evening poster session and dinner reception, held at UCI Applied Innovation, appear on the blog and the April/May 2017 print version. Interviews with CADMIM leadership, IAB members, and attendees are also included in the article. To see the blog version click here: Tech Currents Article

Click to enlarge photo!

Another Cover Page for the Papautsky Group
Congratulations to Ian Papautsky, CADMIM Co-Director, and his research group! Their work is featured on the front cover of the March 9, 2017 issue of Electroanalysis. The cover picture (below) illustrates pre-concentration of Mn2+ ions on a microfabricated Pt thin-film working electrode for point-of-care determination by cathodic stripping voltammetry with 0.9 ppb limit of detection. Paper title: “Determination of manganese by cathodic stripping voltammetry on a microfabricated platinum thin-film electrode.” Complete author list: Wenjing Kang, Pei Xing, Cory Rusinek, Adam Bange, Erin Haynes, William Heineman, and Ian Papautsky. Access article here: Papautsky Group Electroanalysis March 2017.

New Microfluidic Platforms Published by CADMIM Faculty
Michelle Khine, CADMIM Core Faculty at UC Irvine, and lead author graduate students, Michael Chu and Thao Nguyen, have developed a plasma-free process to fabricate both reversibly and irreversibly sealed microfluidic chips using a PDMS-based adhesive polymer mixture. A 3D micromixer was fabricated to demonstrate the irreversible bond. This work, made possible by an NSF research grant only available to I/UCRCs like CADMIM, was published in the January 17, 2017 issue of Lab on a Chip.

Meanwhile, Abe Lee, CADMIM Center Director, and his undergraduate student, Kevin Vittayaruskul, have developed modular microfluidic Lego-like building blocks, that are physically and fluidically connected when assembled. This work was published in the January 24, 2017 issue of the Journal of Micromechanics and Microengineering and has made quite the media splash! It’s been featured, posted, and blogged all over the world including Fast Company, EE Times Europe, and Hackaday.

Congratulations to both groups on developing these innovative microfluidic platforms!


[Left] Khine Lab’s 3D micromixer (blue + gold = green!). [Right] Lego-inspired microfluidics developed in Lee Lab. Click to enlarge photos.

CADMIM Faculty Lead Entrepreneurism
As of February 1, 2017, Jason Heikenfeld, CADMIM Core Faculty, is the new Assistant Vice President for Entrepreneurial Affairs and Technology Commercialization at the University of Cincinnati’s Technology Accelerator for Commercialization (TAC). His responsibilities include providing leadership and oversight for TAC, as well as serving as a key resource and mentor for faculty and staff interested in technology commercialization This position is a reflection of the growing priority and activity in the commercialization technology emerging from the university. Congratulations Jason!

Michelle Khine, CADMIM Core Faculty, has been UC Irvine’s first Director of Faculty Innovation for the Henry Samueli School of Engineering since 2015. Working hand-in-hand with UCI Applied Innovation, she is responsible for facilitating the transfer of innovative engineering research into the marketplace. Michelle will also be inducted to the National Academy of Inventors on April 6, 2017, as part of the Sixth Annual Conference of the National Academy of Inventors in Boston. UCI on-line article with additional details: National Academy of Inventors Article. Congratulations Michelle!


Abe Lee now Editor-in-Chief for Lab on a Chip Journal
Abe Lee, CADMIM Center Director, has accepted a4-year appointment as the next Editor-in-Chief for the Lab on a Chip (LOC) journal (Royal Society of Chemistry). He is replacing Prof. George Whitesides at Harvard starting January 1, 2017. Lab on a Chip is arguably the most influential and reputable journal in the microfluidics field (current impact factor 5.7 and was as high as 7.2 in recent years). Abe is in the process of revamping the editorial board and preparing Thematic Issues from leading opinion leaders in the field. The vision is to build on the leadership position LOC has already established and broaden the scope to become the elite journal at the interface between physical technological advancements and high impact applications that are of direct interest to a broad audience. Congratulations Abe!
UCI on-line article with additional details:
Official announcement published in Lab on a Chip December 2016: LOC_editor_news_2017
Lab on a Chip blog announcement: Lab on a Chip Blog

CADMIM Students Take 3rd Prize at 9th Annual Art in Science Competition
Neha Garg and Dylan Boyle, graduate students in Abe Lee’s lab, won third place at the UCI Art in Science competition, sponsored by The Optics Society and the Beckman Laser Institute November 17th, 2016. There were about 30 entries in the competition, with most entries focusing on interesting micro-scale environments. Neha and Dylan placed with an artisitc photo of green flourescent microparticles trapped in on-chip vortices. The photo is taken with a long exposure, to show the path lines of the particles. The larger fluorescent particles (15 micron) can be selectively separated based on size from small particles (10 micron), using lateral cavity acoustic transducers (LCATs). Researchers in Dr. Lee’s lab are working to utilize such trapping in the isolation of rare cells, such as circulating tumor cells, for patient point-of-care.

News articles about CADMIM
Since the official center launch in April 2014, CADMIM has gained exposure through several news articles:
(1) University of California, Irvine, School of Engineering News:
UCI Engineering News
(2) University of Cincinnati News: U. Cincinnati News
(3) Lab on a Chip announcement: Lab-on-a-Chip News. PDF version here:
Lab-on-a-Chip News (PDF)